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M9490023.TXT
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1994-09-03
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Document 0023
DOCN M9490023
TI [Visceral leishmaniasis in Italy. Its epidemiology, clinical picture and
therapy]
DT 9411
AU Gaeta GB; Gradoni L; Gramiccia M; di Martino L; Pizzuti R; Pempinello R;
Scotti S; Maisto A; Clinica Malattie Infettive, II Universita, Napoli.
SO Recenti Prog Med. 1994 Jun;85(6):340-7. Unique Identifier : AIDSLINE
MED/94323531
AB Visceral leishmaniasis (VL) is a public health problem in most countries
bordering the Mediterranean sea. The disease has been found in central
and southern Italy, Sicily, Sardinia; some pockets are present in
Liguria. Dogs are the reservoirs and the vectors are some species of
sandfly (Phlebotomus species). The incubation period is usually between
2 and 8 months; children and adults may become infected; lethality may
be high and depends upon a correct diagnosis and treatment. The
diagnosis should be suspected on the basis of the epidemiological data
and clinical picture and confirmed by the detection of specific
antibodies by appropriate techniques. Leishmaniasis can be detected in
splenic or bone marrow aspirates. Patients with HIV infection and VL may
lack specific antibodies; parasitological diagnosis is mandatory for
these patients. Antimonials are the classic therapeutic agents for VL.
Recently liposomal amphotericin B (Ambisome) has been successfully used,
with negligible toxicity.
DE Animal Antiprotozoal Agents/THERAPEUTIC USE Disease Reservoirs Dogs
English Abstract Human Insect Vectors Italy/EPIDEMIOLOGY
Leishmaniasis, Visceral/DIAGNOSIS/DRUG THERAPY/*EPIDEMIOLOGY/
TRANSMISSION Phlebotomus Prevalence Support, Non-U.S. Gov't JOURNAL
ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).